Publications

346. Li, Z., L. Liu, L. Unione, Y. Lang, R.J. de Groot, and G.J. Boons. 2022. Synthetic O-acetyl-N-glycolylneuraminic acid oligosaccharides reveal host-associated binding patterns of coronaviral glycoproteins. ACS Inf. Dis. In press (DOI: 10.1021/acsinfecdis.2c00046).

345. Verheyen S, J. Blatterer J, M.R. Speicher, G.S. Bhavini, G.J. Boons, M.M. Ilse, D. Andrae, J. Sproß, F.M. Vaz, S.G. Kircher, L. Posch-Pertl, D. Baumgartner, T. Lübke, H. Shah, A. Al Kaissi, K.M. Girisha, and B. Plecko. 2022. Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency. J. Med. Gen. In press (DOI: 10.1136/jemedgenet-2021-108061).

344. Laman, J.D., R. Huizinga, G.J. Boons, and B.C. Jacobs. 2022. Guillain-Barré syndrome: expanding the concept of molecular mimicry. Trends Immunol. 43(4): 296-308.

343. Spruit, C.M., X. Zhu, I. Tomris, M. Rios Carrasco, A. X. Han, F. Broszeit, R. van der Woude, K.M. Boueman, M.M.T. Luu, K. Matsuno, Y. Sakoda, C.A. Russell, I. A. Wilson, G.J. Boons, and R.P. de Vries. 2022, N-glycolyneuraminic acid binding of avian and equine H7 influenza A viruses. J. Vir. 96(5): e0212021

342. Tomris, I., K.M. Bouwman, Y. Adolfs, D. Noack, R. van der Woude, G. Kerster, S. Herfst, R.W. Sanders, M.J. van Gils, G.J. Boons, B.L. Haagmans, R.J. Pasterkamp, B. Rockx, and R.P. de Vries. 2022. Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns. PLoS Pathog. 18(3): e1010340.

341. Luijkx, Y.M.C.A., A.J. Henselijn, G.P. Bosman, D.A.T. Cramer, C.A.P. Giesbers, E.M. van ‘t Veld, G.J. Boons, A.J.R. Heck, K.R. Reiding, K. Strijbis, and T. Wennekes. 2022. Detection of bacterial α-L-fucosidases with an ortho-quinone methide-based probe and mapping of the probe-protein adducts. Molecules 27(5): 1615.

340. Wu,J., P. Chopra, G.J. Boons, and J. Zaia..2022. Influence of saccharide modifications on heparin lyase III substrate specificities. Glycobiology 32(3): 208-217.

339. Gaide, N., M.N. Lucas, M. Delpont, G. Croville, K.M. Bouwman, A. Papanikolaou, R. van der Woude, I. Gagarinov, G.J. Boons, R.P. de Vries, R. Volmer, A. Teillaud, T. Vergne, C. Bleuart, G, Le Loch, M, Delverdier, and J.L. Guérin. 2022. Pathobiology of highly pathogenic H5 avian influenza viruses in naturally infected Galliformes and Anseriformes in France during winter 2015-2016. Vet. Res. 51(1) 11.

338. Li, Z. L. Unione, L. Liu, Y. Lang, R.P. de Vries, R.J. de Groot, and G.J. Boons. 2022. Synthetic O-acetylated sialosides and their acetamido-deoxy analogs as probes for coronaviral hemagglutinin-esterase recognition. J. Am. Chem. Soc. In press 144(1): 424-435.

337. Nguyen, L. K.A. McCord, D.T. Bui, K.M. Bouwman, E.N. Kitova, M. Elaish, D. Kumawat, G.C. Daskhan, I. Tomris, L. Han, P. Chopra, T.-J. Yang, S.D. Willows, A.L. Mason, L.K. Mahal, T.L. Lowary, L.J. West, S.D. Hsu Y. Hobman, S.M. Tompkins, G.J. Boons, R.P. de Vries, M.S. Macauley, and J.S. Klassen. 2022. Salic acid-dependent binding and viral entry of SARS-CoV-2. Nat. Chem. Biol. 18(1): 81-90.

336. Karlsson, R., P. Chopra. A. Joshi, Z. Zhang, S.Y. Vakhrushev, T. Mandel Clausen, C. D. Painter, G.P. Szekeres, T.-H. Chen, D.R. Sandoval, L. Hansen, J.D. Esko, K. Panel, D.P. Dyer, J.E. Turnbull, H. Clausen*, G. J. Bons*, and R.L. Miller*. 2021. Dissecting structure-function of 3-O-sulfated heparin and engineered heparin sulfates. Sci. Adv. Sci. Adv. 7(52): eabl6026.

335. Meng, X. M.M.S. Wösten, G.J. Boons, and T. Wennekes. 2021. Metabolic labeling of legionaminic acid in flagellin glycosylation of Campylobacter jejuni identifies Maf4 as a putative legionaminyl transferase. Agnew. Chem. Int. Ed. 60(47): 24811-24816.

334. Arunkumar, G.A., D. Bhavsar, T. Li, S. Strohmeier, V. Chromikova, F. Amanat, M. Bunyatov, P.C. Wilson, A.H. Ellebedy, G.J. Boons, V. Simon, R.P. de Cries, and F. Krammer. 2021. Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus. Nat. Commun. 12(1): 6161.

333. Schuurmans, C.C.L., A.J. Brouwer, J.A.W. Jong, G.J.P.H. Boons, W.E. Hennink, and T. Vermonden. 2121. Hydrolytic (in)stability of methacrylate esters in covalently cross-linked hydrogels based on chondroitin sulfate and hyaluronic acid methacrylate. ACS Omega 6(40): 26302-26310.

332. Broszeit, F., R.J. van Beek, L. Unione, T.M. Bestebroer, D. Chapla, J.-Y. Yang, K. W. Moremen, S. Herfst, R.A.M. Voucher, R.P. de Vries, and G.J. Boons. 2021. Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses. Nat. Commun. 12(1): 5449.

331 Huang, J., P. Chopra, L. Liu, T. Nagy, J. Murray, R.A. Tripp, G.J. Boons, and J.J. Mousa. 2021. Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein. J. Virol. 95(18): e00593-21.

330. Srivastava, A.D., L. Unione, M. Bunyatov, I.A. Gagarinov, S. Delgado, N.G.A. Abrescia, A. Ardá, and G.J. Boons. 2021. Chemoenzymatic synthesis of complex N-glycans of the parasite S. mansoni to examine the importance of epitope presentation on DC-SIGN recognition. Angew. Chem. Int. Ed. 60(35): 19287-19296.

329. Moure, M.J., A. Gimeno, S. Delgado, T. Diercks, G.J. Boons, J. Jimenez-Barbero, and A. Arda. 2021. Selective 13C-labels on repeating glycan oligomers to reveal protein binding epitopes through NMR: polylactosamine binding to galectins. Angew. Chem. Int. Ed. 60(34): 18777-18782.

328. Liu, L., P. Chopra, X. Li, K.M. Bouwman, S.M Tompkins, M.A. Wolfert, R.P. de Vries, and G.J. Boons. 2021. Heparan sulfate proteoglycans as an initial attachment factor for SARS-CoV-2. ACS Cent. Sci. 7(6): 1009-1018.

327. Li, Z. Y. Lang, L. Liu, M.I. Bunyatov, A. Isaza Sarmiento, R.J. de Groot, and G.J. Boons. 2021. Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses. Nat. Chem. 13(5): 496-503.

326. Spruit, C.M., N. Nemanichvili, M. Okamatsu, H. Takematsu, H., G.J. Boons, and R.P. de Vries. 2021. N-glycolylneuraminic acid in animal models for human influenza A virus. Viruses 13(5): 815.

325. Bouwman, K.M., I. Tomris, H.L. Turner, R. van der Woude, G.P. Bosman, B. Rockx, S. Herfst, B.L. Haagmans, A.B. Ward, G.J. Boons, and R.P. de Vries. 2021. Multimerization- and glycosylation-dependent receptor binding of SARS CoV-2 spike proteins. PLoS Pathog. 17(2): e1009282.

324. Sastre Toraño, J., O. Aizpurua-Olaizola, N. Wei, T. Li, L. Unione, G. Jiménez-Osés, F. Corzana, V.J. Somovilla, J.M. Falcon-Perez, and G.J. Boons. 2021. Identification of isomeric N-glycans by conformer distribution fingerprinting using ion mobility-mass spectrometry. Chem. Eur. J. 26(6): 2149-2154.

323. Chopra, P., A. Joshi, J. Wu, W. Lu, T. Yadavalli, M.A. Wolfert, D. Shukla, J. Zaia, and G.J. Boons. 2021. 3-O-Sulfation of heparan sulfate modulates protein binding and lyase degradation. Proc. Natl. Acad. Sci. U. S. A. 118(3): e2012935118.

322.   Overeem, N.J., P.H.E. Hamming, O.C. Grant, D. Di Iorio, M. Tieke, M.C. Bertolino, Z. Li, G. Vos, R.P. de Vries, R.J. Woods,* N.B. Tito, G.J.P.H. Boons,* E. van der Vries,* and J. Huskens*. 2020. Hierarchical multivalent effects control influenza host specificity. ACS Cent. Sci. 6(12): 2311−2318.

321.   Sun, L., P. Chopra, and G.J. Boons. 2020. Modular synthesis of heparan sulfate oligosaccharides having N-acetyl and N-sulfate moieties. J. Org. Chem. 85(24): 16082-16098.

320.   Boruah, B.M., R. Kadirvelraj, L. Liu, A. Ramiah, C. Li, G. Zong, G.P. Bosman, J.-Y. Yang, L.-X. Wang, G.J. Boons, Z.A. Wood, and K.W. Moremen. 2020. Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases. J. Biol. Chem. 295(50): 17027-17045.

319.   Verpalen, E.C.J.M., A.J. Brouwer, and G.J. Boons. 2020. Synthesis of monophosphoryl lipid A using 2-naphtylmethyl ethers as permanent protecting groups. Carbohydr. Res. 498: 108152.

318.   Srivastava, A.D., L. Unione, M.A. Wolfert, P. Valverde, A. Ardá, J. Jiménez-Barbero, and G.J. Boons. 2020. Mono- and di-fucosylated glycans of the parasitic worm S. mansoni are recognized differently by the innate immune receptor DC-SIGN. Chem. Eur. J. 26(67): 15605-15612. Selected as “Hot Paper”

317.   Li, T., M.A. Wolfert, N. Wei, R. Huizinga, B.C. Jacobs, and G.J. Boons. 2020. Chemoenzymatic synthesis of Campylobacter jejuni lipo-oligosaccharide core domains to examine Guillain-Barré syndrome serum antibody specificities. J. Am. Chem. Soc. 142(46): 19611-19621.

316.   Williams, C.R., L. Chen, E.S. Sheppard, P. Chopra, J. Locklin, G.J. Boons, and D.C. Krause. 2020. Distinct Mycoplasma pneumoniae interactions with sulfated and sialylated receptors. Infect. Immun. 88(11): e00392-20.

315.   Lang, Y., W. Li, Z. Li, D. Koerhuis, A.C.S. van den Burg, E. Rozemuller, B.-J. Bosch, F.J.M. van Kuppeveld, G.J.P.H. Boons, E.G. Huizinga, H.M. van der Schaar, and R.J. de Groot. 2020. Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity. Proc. Natl. Acad. Sci. U. S. A. 117(41): 25759-25770.

314.   Trabszo,C. B. Ramms, P. Chopra, R. Lüllmann-Rauch, S. Stroobants, J. Sproß, A. Jeschke, T. Schinke, G.J. Boons, J.D. Esko, T. Lübke, and T. Dierks. 2020. Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate. Biochem. J. 477(17): 3433-3451.

313.   Du, W. M.A. Wolfert, B. Peeters, F.J.M. van Kuppeveld, G.J. Boons, E. de Vries, and C.A.M. de Haan. 2020. Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin. PloS Pathog. 16(8): e1008816.

312.   Lettow, M., M. Grabarics, K. Greis, E. Mucha, D. Thomas, P. Chopra, G.J. Boons, R. Karlsson, J. Turnbull, G. Meijer, R. Miller, G. von Helden, and K. Pagel. 2020. Cryogenic infrared spectroscopy reveals structural modularity in the vibrational fingerprints of heparan sulfate diastereomers. Anal. Chem. 92(15): 10228-10232.

311.   Jansen, A.J.G., T. Spaan, H.Z. Low, D. Di Iorio, J. van den Brand, M. Tieke, A. Barendrecht, K. Rohn, G. van Amerongen, K. Stittelaar, W. Baumgärtner, A. Osterhaus, T. Kuiken, G.J. Boons, J. Huskens, M. Boes, C. Maas, and E. van der Vries. 2020. Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity. Blood Adv. 4(13): 2967-2978.

310.   Shrestha, S., S. Katiyar, C.E. Sanz-Rodriguez, N.R. Kemppinen, H.W. Kim, R. Kadirvelraj, C. Panagos, N. Keyhaninejad, M. Colonna, P. Chopra, D.P. Byrne, G.J. Boons, E.V. Knaap, P.A. Eyers, A.S. Edison, Z.A. Wood, and N. Kannan. 2020. A novel redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily. Sc. Signaling. 13(639): eaax6313.

309.   Eggink D., M. Spronken, R. van der Woude, J. Buzink, F. Broszeit, R. McBride R, H.A. Pawestri, V. Setiawaty, J.C. Paulson, G.J. Boons, R.A.M. Fouchier, C.A. Russell, M.D. de Jong, and R.P. de Vries. 2020. Phenotypic effects of substitutions within the receptor binding site of highly pathogenic avian influenza H5N1 virus observed during human infection. J. Virol. 94(13): e00195-20.

308.   Talsma, D.T., F. Poppelaars, W.A Dam, A.H Meter-Arkema, R.R Vives, P. Gál, G.J.P.H. Boons, P. Chopra, A. Naggi, M. Seelen, S. Philip Berger, M. Daha, C.A. Stegeman, and J. van den Born. 2020. MASP-2 is a heparin-binding protease; Identification of blocking oligosaccharides. Front. Immunol. 11: 732.

307.  Dumas, E.K., H. Demiraslan, R.J. Ingram, R.M. Sparks, E. Muns, A. Zamora, J. Larabee, L. Garman, J. Ballard, G.J. Boons, J.A. James, Ü. Kayabas, M. Doganay, and A.D. Farris. 2020. Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes. PLoS ONE 15(4): e0230782.

306.   Miller, R.L., S.E. Guimond, R. Schwörer, O.V. Zubkova, P.C. Tyler, Y. Xu, J. Liu, P. Chopra, G.J. Boons, M. Grabarics, C. Manz, J. Hofmann, N. Karlsson, J.E. Turnbull, W.B. Struwe, and K. Pagel. 2020. Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides. Nat. Commun. 11(1): 1481.

305.   Singh, J., C. Her, N. Supekar, G.J. Boons, V.V. Krishnan, and C.L. Brooks. 2020. Role of glycosylation on the ensemble of conformations in the MUC1 immunodominant epitope. J. Pept. Sc. 26(1): e3229.

304. Sastre Toraño, J., I.A. Gagarinov, G.M. Vos, F. Broszeit, A.D. Srivastava, M. Palmer, J.I. Langridge, O. Aizpurua-Olaizola, V.J. Somovilla, and G.J. Boons. 2019. Ion-mobility spectrometry can assign exact fucosyl positions in glycans and prevent misinterpretation of mass spectrometry data after gas-phase rearrangement. Angew. Chem. Int. Ed. 58(49): 17616-17620.

303. Hoeksma, J., T. Misset, C. Wever, J. Kemmink, J. Kruijtzer, K. Versluis, r.M.J. Liskamp, G.J. Boons, A.J.R. Heck, T. Boekhout, and J. den Hertog. 2019. A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out. Sc. Rep. 9(1): 17546.

302. Liu, H., A. Joshi, P. Chopra, L. Liu, G.J. Boons, and J.S. Sharp. 2019. Salt-free fractionation of complex isomeric mixtures of glycosaminoglycan oligosaccharides compatible with ESI-MS and microarray analysis. Sc. Rep. 9(1): 16566.

301. Chopra, P., M.T. Logun, E.M. White, W. Lu, J. Locklin, L. Karumbaiah, and G.J. Boons. 2019. Fully synthetic heparan sulfate-based neural tissue construct that maintains the undifferentiated state of neural stem cells. ACS Chem. Biol. 14(9): 1921-1929.

300. Gray, C.J., L.G, Migas, P.E. Barran, K. Pagel, P.H. Seeberger, C.E. Eyers, G.J. Boons, N.L.B. Pohl, I. Compagnon, G. Widmalm, and S.L. Flitsch. 2019. Advancing solutions to the carbohydrate sequencing challenges. J. Am. Chem. Soc. 141(37): 14463-14479.

299. Wu, J., J. Wei, P. Chopra, G.J. Boons, C. Lin, and J. Zaia. 2019. Sequencing heparan sulfate using HILIC LC-NETD-MS/MS. Anal. Chem. 91(18): 11738-11746.

298. t’ Hart, I.M.E.,T. Li, M.A. Wolfert, S. Wang, K.W. Moremen, and G.J. Boons. 2019. Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide. Org. Biomol. Chem. 17(31): 7304-7308.

297. Gagarinov, I.A., T. Li, N. Wei, J. Sastre Toraño, R.P. de Vries, M.A. Wolfert, and G.J. Boons. 2019. Protecting group-controlled enzymatic glycosylation of oligo-N-acetyllactosamine derivatives. Angew. Chem. Int. Ed. 58(31): 10547-10552.

296. Lu, W., W. Du, V.J. Somovilla, G. Yu, D. Haksar, E.J. de Vries, G.J. Boons, R.P. de Vries, C.A.M. de Haan, and R.J. Pieters. 2019. Enhanced inhibition of influenza A virus adhesion by di- and trivalent hemagglutinin inhibitors. J. Med. Chem. 62(13): 6398-6404.

295. Broszeit, F., N. Tzarum, X. Zhu, N. Nemanachvilli, D. Eggink, T. Leenders, Z. Li, L. Liu, M.A. Wolfert, A. Papanikolaou, C. Martinez-Romero, I.A. Gagarinov, W. Yu, A. Garcia-Sastre, T. Wennekes, M. Okamatsu, M.H. Verheije, I.A. Wilson, G.J. Boons, and R.P. de Vries. 2019. N-glycolylneuraminic acid as a receptor for influenza A viruses. Cell Rep. 27(11): 3284-3294.e6.

294. Du, W., H. Guo, V.S. Nijman, J. Doedt, E. van der Vries, J. van der Lee, Z. Li, G.J. Boons, F.J.M. van Kuppeveld, E. de Vries, M. Matrosovich, and C.A.M. de Haan. 2019. The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathog. 15(6):e1007860.

293. Tortorici, A. M., A.C. Walls, Y. Lang, C. Wang, Z. Li, D. Koerhuis, G.J. Boons, B.J. Bosch, F.A. Rey, R.J. de Groot, and D. Veesler. 2019. Structural basis for human coronavirus attachment to sialic acid receptors. Nat. Struct. Mol. Biol. 26(6): 481-489.

292. Bouwman, K.M., M. Delpont, F. Broszeit, R. Berger, E.A.W.S. Weerts, M.-N. Lucas, M. Delverdier, S. Belkasmi, A. Papanikolaou, G.J. Boons, J.-L. Guérin, R.P. de Vries, M.F. Ducatez, M.H. Verheij. 2019. Guinea fowl coronavirus diversity has phenotypic consequences for glycan and tissue binding. J. Virol. 93(10): e00067-19.

291. Hu, Y., X. Cao, X. Li, Y. Wang, G.J. Boons, J. Deng, H. Jiang. 2019.The three-dimensional structure and recognition mechanism of Manduca sexta peptidoglycan recognition protein-1. Insect Biochem. Mol. Biol. 108: 44-52.

290. van der Beek, S.L., A. Zorzoli, E. Çanak, R.N. Chapman, B.H. Meyer, D. Evangelopoulos, L.P.S. de Carvalho, G.J. Boons, H.C. Dorfmueller, and N.M. van Sorge. 2019. Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification. Mol. Microbiol. 111(4): 951-964.

289. Li, T., L. Liu, N. Wei, J.-Y. Yang, D.G. Chapla, K.W. Moremen, and G.J. Boons. 2019. An automated platform for the enzyme-mediated assembly of complex oligosaccharides. Nat. Chem. 11(3): 229-236. Highlighted in Nat. Chem. News & Views: Pohl, N.L.B. 2019. Robots command enzymes. Nat. Chem. 11(3): 201-203.

288. Nemanachvili, N., I. Tomris, H.L. Turner, R. McBride, O.C. Grant, R. van der Woude, M.H. Aldosari, R.J. Pieters, R.J. Woods, J.C. Paulson, G.J. Boons, A.B. Ward, M.H. Verheije, and R.P. de Vries. 2019. Fluorescent trimeric hemagglutinins reveal multivalent receptor-binding properties. J. Mol. Biol. 431(4): 842-856.

287. Hulswit, R.J.G., Y. Lang, M.J.G. Bakkers, W. Li, Z. Li, A. Schouten, B. Ophorst, F.J.M. van Kuppeveld, G.J. Boons, B.J. Bosch, E.G. Huizinga, and R.J. de Groot. 2019. Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor binding site in spike protein domain A. Proc. Natl. Acad. Sci. U. S. A. 16(7): 2681-2690.

286. Liu, L., A.R. Prudden, C.J. Capicciotti, G.P. Bosman, J.-Y. Yang, D.G. Chapla, K.W. Moremen, and G.J. Boons. 2019. Streamlining the chemoenzymatic synthesis of complex N-glycans by a stop and go strategy. Nat. Chem. 11(2): 161-169.

285. Marcelo, F., N. Supekar, F. Corzana, J.C. van der Horst, I.M. Vuist, D.H Live, G.J. Boons, D.F. Smith, and S.J. van Vliet. 2019. Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands. J. Biol. Chem. 294(4): 1300-1311.

284. Chapman, R.N., L. Liu, and G.J. Boons. 2018. 4,6-O-Pyruvyl ketal modified N-acetylmannosamine of the secondary cell wall polysaccharide of Bacillus anthracis is the anchoring residue for its surface layer proteins. J. Am. Chem. Soc. 140(49): 17079–17085.

283. Du, W., M. Dai, Z. Li, G.J. Boons, B. Peeters, F.J.M. van Kuppeveld, E. de Vries, and C.A.M. de Haan. 2018. Substrate binding by the second sialic acid-binding site of influenza A virus N1 neuraminidase contributes to enzymatic activity. J. Virol. 92(20): e01243-18.

282. Moure, M.J., A. Eletsky, Q. Gao, L.C. Morris, J.-Y. Yang, D. Chapla, Y. Zhao, C. Zong, I.J. Amster, K.W. Moremen, G.J. Boons, and J.H. Prestegard. 2018. Paramagnetic tag for glycosylation sites in glycoproteins: Structural constraints on heparan sulfate binding to Robo1. ACS Chem. Biol. 13(9): 2560-2567.

281. Yu, S.-H., P. Zhao, P.K. Prabhakar, T. Sun, A. Beedle, G.J. Boons, K.W. Moremen, L. Wells, and R. Steet. 2018. Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases. J. Biol. Chem. 293(37): 14534-14544.

280. Yi, F., X. Hong, A.B. Kumar, C. Zong, G.J. Boons, C.R. Scott, F. Turecek, B.H. Robinson, and M.H. Gelb. 2018. Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry. Mol. Genet. Metab. 125(1-2): 59-63.

279. Liang Q., P. Chopra, G.J. Boons, and J.S. Sharp. 2018. Improved de novo sequencing of heparin/heparan sulfate oligosaccharides by propionylation of sites of sulfation. Carbohydr. Res. 465: 16-21.

278. Hogan, J.D., J.A. Klein, J. Wu, P. Chopra, G.J. Boons, L. Carvalho, C. Lin, and J. Zaia. 2018. Software for peak finding and elemental composition assignment for glycosaminoglycan tandem mass spectra. Mol. Cell. Proteomics 17(7): 1448-1456.

277. Chinoy, Z.S., F. Friscourt, C. Capicciotti, P. Chiu, and G.J. Boons. 2018. Chemoenzymatic synthesis of asymmetrical multi-antennary N-glycans to dissect glycan-mediated interactions between human sperm and oocytes. Chem. Eur. J. 24(31): 7970-7975. Selected as a VIP paper.

276. Wu, J., J. Wei, J.D. Hogan, P. Chopra, A. Joshi, W. Lu, J.A. Klein, G.J. Boons, C. Lin, and J. Zaia. 2018. Negative electron transfer dissociation sequencing of 3-O-sulfation-containing heparan sulfate oligosaccharides. J. Am. Soc. Mass Spectrom. 29(6): 1262-1272.

275. Zhao Y., J.Y. Yang, D.F. Thieker, Y. Xu, C. Zong, G.J. Boons, J. Liu, R.J. Woods, K.W. Moremen, I.J. Amster. 2018. A traveling wave ion mobility spectrometry (TWIMS) study of the Robo1-heparan sulfate interaction. J. Am. Soc. Mass Spectrom. 29(6): 1153-1165.

274. Lu, W., C. Zong, P. Chopra, L. Pepi, Y. Xu, I.J. Amster, J. Liu, and G.J. Boons. 2018. Controlled chemoenzymatic synthesis of heparan sulfate oligosaccharides. Angew. Chem. Int. Ed. 57(19): 5340-5344.

273. Kadirvelraj, R., J.-Y. Yang, J.H. Sanders, L. Liu, A. Ramiah, P.K. Prabhakar, G.J. Boons, Z.A. Wood, and K.W. Moremen. 2018. Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc. Natl. Acad. Sci. U. S. A. 115(18): 4637-4642.

272. Sychantha, D., R. Chapman, N.C. Bamford, G.J. Boons, P.L. Howell, and A.J. Clarke. 2018. Molecular basis for the attachment of S-layer proteins to the cell wall of Bacillus anthracis. Biochemistry 57(13): 1949-1953.

271. Williams C., F. Royo, O. Aizpurua-Olaizola, R. Pazos, G.J. Boons, N.-C. Reichardt, and J.M. Falcon-Perez. 2018. Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives. J. Extracell. Vesicles. 7(1): 1442985.

270. Aizpurua-Olaizola O., J. Sastre Toraño, J.M. Falcon-Perez, C. Williams, N. Reichardt, and G.J. Boons. 2018. Mass spectrometry for glycan biomarker discovery. Trends Anal. Chem. 100: 7-14.

269. Aizpurua-Olaizola O., J. Sastre Toraño, A.V. Pukin, O. Fu, G.J. Boons, G.J. de Jong, and R.J. Pieters. 2018. Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors. Electrophoresis 39(2): 344-347.

268. Supekar, N.T., V. Lakshminarayanan, C. Capicciotti, A. Sirohiwal, C.S. Madsen, M.A. Wolfert, P.A. Cohen, S.J. Gendler, and G.J. Boons. 2018. Synthesis and immunological evaluation of a multicomponent cancer vaccine candidate containing a long MUC1 glycopeptide. ChemBioChem 19(2): 121-125.

267. Sychantha, D., D.J. Little, R.N. Chapman, G.J. Boons, H. Robinson, P.L. Howell, and A.J. Clarke. 2018. PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides. Nat. Chem. Biol. 14(1): 79-85.

266. Moure, M.J., Y. Zhuo, G. J. Boons*, and J. H. Prestegard*. 2017. Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase. Chem. Commun. 53(92): 12398-12401.

265. Liu, L., A.R. Prudden, G.P. Bosman, and G.J. Boons. 2017. Improved isolation and characterization procedure of sialylglycopeptide from egg yolk powder. Carbohydr. Res. 452: 122-128.

264. Klamer, Z., B. Staal, A.R. Prudden, L. Liu, D.F. Smith, G.J. Boons, and B. Haab. 2017. Mining high-complexity motifs in glycans: a new language to uncover the fine-specificities of lectins and glycosidases. Anal. Chem. 89(22): 12342-12350.

263. Benedetti, E., M. Pučić-Baković, T. Keser, A. Wahl, A. Hassinen, J.Y. Yang, L. Lui, I. Trbojević Akmačić, G. Razdorov, J. Štambuk, L. Klarić, I. Ugrina, M.H.J. Selman, M. Wuhrer, I. Rudan, O. Polasek, C. Hayward, H. Grallert, K. Strauch, A. Peters, T. Meitinger, C. Gieger, M. Vilaj, , G.J. Boons, K.W. Moremen, T. Ovchinnikova, N. Bovin, S. Kellokumpu, F.J. Theis, G. Lauc, and J. Krumsiek. 2017. Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Nat. Commun. 8: 1483. (Erratum author affiliation in: Nat. Commun. 2018 9(1): 706).

262. Capicciotti, C.J., C. Zong, M.O. Sheikh, T. Sun, L. Wells, and G.J. Boons. 2017. Cell-surface glyco-engineering by exogenous enzymatic transfer using a bifunctional CMP-Neu5Ac derivative. J. Am. Chem. Soc. 139(38): 13342-13348. Highlighted in ACS Chem. Biol.: Underwood, J.G. 2017. Synthetic décor on the extracellular canvas. ACS Chem. Biol. 12: 2480-2481.

261. Agyekum, I., C. Zong, G.J. Boons, J, and I.J. Amster. 2017. Single stage tandem mass spectrometry assignment of the C-5 uronic acid stereochemistry in heparan sulfate tetrasaccharides using electron detachment dissociation. J. Am. Soc. Mass Spectrom. 28(9): 1741-1750.

260. Ding, N., X. Li, Z.S. Chinoy, and G.J. Boons. 2017. Synthesis of a glycosylphosphatidylinositol anchor derived from Leishmania donovani that can be functionalization by Cu-catalyzed azide-alkyne cycloadditions. Org. Lett. 19(14): 3827-3830.

259. Zong, C., A. Venot, X. Li, W. Lu, W. Xiao, J.L. Wilkes, C.L. Salanga, T.M. Handel, L. Wang, M.A. Wolfert, and G.J. Boons. 2017. Heparan sulfate microarray reveals that heparan sulfate-protein binding exhibits different ligand requirements J. Am. Chem. Soc. 139(28): 9534-9543.

258. Lin, A.E., C.A. Autran, A. Szyszka, T. Escajadillo, M. Huang, K. Godula, A.R. Prudden, G.J. Boons, A.L. Lewis, K.S. Doran, V. Nizet, and L. Bode. 2017. Human milk oligosaccharides inhibit growth of group B Streptococcus. J. Biol. Chem. 292(27): 11243-11249.

257. Prudden, A.R., L. Liu, C.J. Capicciotti, M.A. Wolfert, S. Wang, Z. Gao, L. Meng, K.W. Moremen, and G.J. Boons. 2017. Synthesis of asymmetrical multiantennary human milk oligosaccharides. Proc. Natl. Acad. Sci. U. S. A. 114(27): 6954-6959.

256. Movahedin, M., T.M. Brooks, N.T. Supekar, N. Gokanapudi, G.J. Boons, and C.L. Brooks. 2017. Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen. Glycobiology 27(7): 677-687.

255. Dhamale, O., R.E. Lawrence, E.M. Wiegmann, B.A. Shah, K. al-Mafraji, W.C. Lamanna, T. Lübke, T. Dierks, G.J. Boons, and J.D. Esko. 2017. Arylsulfatase K is the lysosomal 2-sulfogluronate sulfatase. ACS Chem. Biol. 12(2): 367-373.

254. Halmo, S.M., D. Singh, S. Patel, S. Wang, M. Edlin, G.J. Boons, K.W. Moremen, D. Live, and L. Wells. 2017. Protein O-linked mannose β-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) is a gatekeeper enzyme for functional glycosylation of α-dystroglycan. J. Biol. Chem. 292(6): 2101-2109.

253. Gagarinov, I.A., T. Li, J. Sastre Toraño, T. Caval, A.D. Srivastava, J.A.W. Kruijtzer, A.J.R. Heck, and G.J. Boons. 2017. Chemoenzymatic approach for the preparation of asymmetric bi-, tri- and tetra-antennary N-glycans from a common precursor. J. Am. Chem. Soc. 139(2): 1011–1018.

252. Zhao, Y., A. Singh, Y. Xu, C. Zong, F. Zhang, G.J. Boons, J. Liu, R.J. Linhardt, R.J. Woods, and I.J. Amster. 2017. Gas-phase analysis of the complex of fibroblast growth factor 1 with heparan sulfate: a traveling wave ion mobility spectrometry (TWIMS) and molecular modeling study. J. Am. Soc. Mass Spectrom. 28(1): 96-109.

251. Li, T., M. Huang, L. Liu, S. Wang, K.W. Moremen, and G.J. Boons. 2016. Divergent chemoenzymatic synthesis of asymmetrical core fucosylated and core-unmodified N-glycans. Chem. Eur. J. 22(52): 18742-18746.

250. Gao, Q., C.-Y. Chen, C. Zong, S. Wang, A. Ramiah, P. Prabhakar, L. Morris, G.J. Boons, K. Moremen, and J. Prestegard. 2016. Structural aspects of heparan sulfate binding to Robo1-Ig1-2. ACS Chem. Biol. 11(11): 3106-3113.

249. Singh, A., M.B. Tessier, K. Pederson, X. Wang, A.P. Venot, G.J. Boons, J.H. Prestegard, and R.J Woods. 2016. Extension and validation of the GLYCAM force field parameters for modeling glycosaminoglycans. Can. J. Chem. 94(11): 927-935.

248. Zong, C., R. Huang, E. Condac, Y. Chiu, W. Xiao, X. Li, W. Lu, M. Ishahara, S. Wang, A. Ramiah, M. Stickney, P. Azadi, I.J. Amster, K.W. Moremen, L. Wang, J.S. Sharp, and G.J. Boons. 2016. Integrated approach to identify heparan sulfate ligand requirements of Robo1. J. Am. Chem. Soc. 138(39): 13059−13067.

247. Bode, L., N. Contractor, D. Barile, N. Pohl, A. Prudden, G.J. Boons, Y.-S. Jin, and S. Jennewein. 2016. Overcoming the limited availability of human milk oligosaccharides: challenges and opportunities for research and application. Nutr. Rev. 74(10): 635-644.

246. Sun, T., S.-H. Yu, P. Zhao, L. Meng, K.W. Moremen, L. Wells, R. Steet, and G.J. Boons.. 2016. One-step selective exoenzymatic labeling (SEEL) strategy for the biotinylation and identification of glycoproteins of living cells. J. Am. Chem. Soc. 138(36): 11575-11582.

245. Li, X., S.J.H. Martin, Z.S. Chinoy, L. Liu, B. Rittgers, R.A. Dluhy, and G.J. Boons. 2016. Label-free detection of glycan-protein interactions for array development by Surface Enhanced Raman Spectroscopy (SERS). Chem. Eur. J. 22(32): 11180-11185.

244. Bakkers, M.J.G., Q. Zeng, L.J. Feitsma, R.J.G. Hulswit, Z. Li, A. Westerbeke, F.J.M. van Kuppeveld, G.J. Boons, M.A. Langereis, E.G. Huizinga, and R.J. de Groot. 2016. Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation. Proc. Natl. Acad. Sci. U. S. A. 113(22): E3111-E3119.

243. Huang, R., C. Zong, A. Venot, Y. Chiu, D. Zhou, G.J. Boons, and J.S. Sharp. 2016. De novo sequencing of complex mixtures of heparan sulfate oligosaccharides. Anal. Chem. 88(10): 5299-5307.

242. Wang, K., F. Friscourt, C. Dai, L. Wang, Y. Zheng, G.J. Boons, S. Wang, and B. Wang. 2016. A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides. Bioorg. Medicinal Chem. Lett. 26(7): 1651-1654. Coverage in Synform: Synform 2016/09: A131–A134.

241. Fang, T., Y. Gu, W. Huang, and G.J. Boons. 2016. Mechanism of glycosylation of anomeric sulfonium ions. J. Am. Chem. Soc. 138(9): 3002-3011.

240. Ríos, P., T.S. Carter, T.J. Mooibroek, M.P. Crump, M. Lisbjerg, M. Pittelkow, N.T. Supekar, G.J. Boons, and A.P. Davis. 2016. Synthetic receptors for high-affinity recognition of O-GlcNAc derivatives. Angew. Chem. Int. Ed. 55(10): 3387-3392.

239. Martínez-Sáez, N., N.T. Supekar, M.A. Wolfert, I.A. Bermejo, R. Hurtado-Guerrero, J.L. Asensio, J. Jiménez-Barbero, J.H. Busto, A. Avenoza, G.J. Boons, J.M. Peregrina, and F. Corzana. 2016. Mucin architecture behind the immune response: design and evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment. Chem. Sc. 7(3): 2294-2301.

238. Yu, S.-H., P. Zhao, T. Sun, Z. Gao, K.W. Moremen, G.J. Boons, L. Wells, and R. Steet. 2016. Selective exo-enzymatic labeling detects increased cell surface sialoglycoprotein expression upon megakaryocytic differentiation. J. Biol. Chem. 291(8): 3982-3989.

237. Hudlikar, M.S., X. Li, I.A. Gagarinov, N. Kolishetti, M.A. Wolfert, and G.J. Boons. 2016. Controlled multi-functionalization facilitates targeted delivery of nanoparticles to cancer cells. Chem. Eur. J. 22(4): 1415-1423.

236. Lakshminarayanan V., N.T. Supekar, J. Wei, D.B. McCurry, A.C. Dueck, H.E. Kosiorek, P.P. Trivedi, J.M. Bradley, C.S. Madsen, L.B. Pathangey, D. Hoelzinger, M.A. Wolfert, G.J. Boons, P.A. Cohen, and S.J. Gendler. 2016. MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice. PLoS ONE 11(1): e0145920.

235. van der Beek, S.L., Y. Le Breton, A.T. Ferenbach, R.N. Chapman, D.M.F. van Aalten, I. Navratilova, G.J. Boons, K.S. McIver, N.M. van Sorge, and H.C. Dorfmueller. 2015. GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD). Mol. Microbiol. 98(5): 946-962.

234. Agyekum, I., A.B. Patel, C.L. Zong, G.J. Boons, and I.J. Amster. 2015. Assignment of hexuronic acid stereochemistry in synthetic heparan sulfate tetrasaccharides with 2-O-sulfo uronic acids using electron detachment dissociation. Int. J. Mass Spectrom. 390: 163-169.

233. Friscourt, F., C.J. Fahrni, and G.J. Boons. 2015. Fluorogenic strain-promoted alkyne-diazo cycloadditions. Chem. Eur. J. 21(40): 13996-14001.

232. Huang, W., Q. Gao, and G.J. Boons. 2015. Assembly of a complex branched oligosaccharide by combining fluorous-supported synthesis and stereoselective glycosylations using anomeric sulfonium ions. Chem. Eur. J. 21(37): 12920-12926. Selected for frontispiece.

231. Liu, L., J. Zha, A. DiGiandomenico, D. McAllister, C.K. Stover, Q. Wang, and G.J. Boons. 2015. Synthetic enterobacterial common antigen (ECA) for the development of a universal immunotherapy for drug-resistant Enterobacteriaceae. Angew. Chem. Int. Ed. 54(37): 10953-10957. Press release by Angew. Chem. Int. Ed. News Room (Juli 31, 2015): Sugar Antigen Lost its Resistance. Successful chemical synthesis of enterobacterial common antigen relevant for immunotherapy. Highlighted in C&EN: Borman, S. A. 2015. Enterobacterial antigen analogs synthesized. Carbohydrate chemistry: Protein conjugates of the antigen could serve as vaccines for pathogenic bacteria. Chemical & Engineering News, 93(32): 50.

230. Chinoy, Z.S., C.M. Schafer, C.M. West, and G.J. Boons. 2015. Chemical synthesis of a glycopeptide derived from Skp1 for probing protein specific glycosylation. Chem. Eur. J. 21(33): 11779–11787.

229. Ledin, P.A., W. Xu, F. Friscourt, G.J. Boons, and V. Tsukruk. 2015. Branched polyhedral oligomeric silsesquioxane nanoparticles prepared via strain-promoted 1,3-dipolar cycloadditions. Langmuir 31(29): 8146–8155.

228. Thompson, P., V. Lakshminarayanan N.T. Supekar, J.M. Bradley, P.A. Cohen, M.A. Wolfert, S.J. Gendler, and G.J. Boons. 2015. Linear synthesis and immunological properties of a fully synthetic vaccine containing a sialylated MUC1 glycopeptide. Chem. Commun. 51(50): 10214-10217.

227. Gagarinov, I.A., T. Fang, L. Liu, A.D. Srivastava, and G.J. Boons. 2015. Synthesis of Staphylococcus aureus Type 5 trisaccharide repeating unit: solving the problem of lactamization. Org. Lett. 17(4): 928-931.

226. Forestier, C.L. Q. Gao, and G.J. Boons. 2015. Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate? Front. Cell. Infect. Microbiol. 4 (Aricle 193): 1-7.

225. Huang, Y., Y. Mao, C. Zhong, C. Lin, G.J. Boons, and J. Zaia. 2015. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal. Chem. 87(1): 592-600.

224. Praissman, J.L., D.H. Live, S. Wang, A. Ramiah, Z.S. Chinoy, G.J. Boons, K.W. Moremen, and L. Wells. 2014. B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of -dystroglycan. eLife 3: e03943.

223. Hu, H., Y. Huang, Y. Mao, X. Yu, Y. Xu, J. Liu, C. Zong, G.J. Boons, C. Lin, Y. Xia, and J. Zaia. 2014. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Mol. Cell. Proteomics 13(9): 2490-2502.

222. Prudden, A.R., Z.S. Chinoy, M.A. Wolfert, and G.J. Boons. 2014. A multifunctional anomeric linker for the chemoenzymatic synthesis of complex oligosaccharides. Chem. Commun. 50(54): 7132-7135.

221. Li, X., T. Fang, and G.J. Boons. 2014. Preparation of well-defined antibody–drug conjugates through glycan remodeling and strain-promoted azide–alkyne cycloadditions. Angew. Chem. Int. Ed. 53(28): 7179-7182.

220. Abdel Aal, A.M., V. Lakshminarayanan, P. Thompson, N. Supekar, J.M. Bradley, M.A. Wolfert, P.A. Cohen, S.J. Gendler, and G.J. Boons. 2014. Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist. ChemBioChem 15(10): 1508-1513.

219. Ledin, P.A., N. Kolishetti, M.S. Hudlikar, and G.J. Boons. 2014. Exploring strain-promoted 1,3-dipolar cycloadditions on end functionalized polymers. Chem. Eur. J. 20(28): 8753-8760.

218. Arumugam, S., J. Guo, N.E. Mbua, F. Friscourt, N. Lin, E. Nekongo, G.J. Boons, and V.V. Popik. 2014. Selective and reversible photochemical derivatization of cysteine residues in peptides and proteins. Chem. Sci. 5(4): 1591-1598.

217. Dhamale, O.P., C. Zhong, K. Al-Mafraji, and G.J. Boons. 2014. New glucuronic acid donors for the modular synthesis of heparan sulfate oligosaccharides. Org. Biomol. Chem. (12): 2087-2098.

216. Kailemia M.J., M. Park, D.A. Kaplan, A. Venot, G.J. Boons, L. Li, R.J Linhardt, and I.J. Amster. 2014. High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation for isobaric mixtures of glycosaminoglycans. J. Am. Soc. Mass Spectrom. 25(2): 258-268.

215. Li, H., K. Mo, Q. Wang, C.K. Stover, A. DiGiandomenico, and G.J. Boons. 2013. Epitope mapping of monoclonal antibodies using synthetic oligosaccharides uncovers novel aspects of immune recognition of the Psl exopolysaccharide of Pseudomonas aeruginosa. Chem. Eur. J. 19(51): 17425-17431.

214. Live, D., L. Wells, and G.J. Boons. 2013. Dissecting the molecular basis for the role of the O-mannosylation pathway in disease: alpha-dystroglycan and forms of muscular dystrophy. ChemBioChem 14(18): 2392-2402.

213. Mbua, N.E., X. Li, H. Flanagan-Steet, L. Meng, K. Aoki, K.W. Moremen, M.A. Wolfert, R. Steet, and G.J. Boons. 2013. Selective exo-enzymatic labeling of N-glycans of living cells by recombinant ST6Gal I. Angew. Chem. Int. Ed. 52(49): 13012-13015. Selected as “Hot Paper”.

212. Wolfert, M.A. and G.J. Boons. 2013. Adaptive immune activation: glycosylation does matter. Nat. Chem. Biol. 9(12): 776-784.

211. Ledin, P.A., N. Kolishetti, and G.J. Boons. 2013. Multifunctionalization of polymers by strain-promoted cycloadditions. Macromolecules 46(19): 7759-7768.

210. Heimburg-Molinaro J., J.W. Priest, D. Live, G.J. Boons, X. Song, R.D. Cummings, and J.R. Mead. 2013. Microarray analysis of the human antibody response to synthetic Cryptosporidium glycopeptides. Int. J. Parasitol. 43(11): 901-907.

209. Kaeothip, S. and G.J. Boons. 2013. Chemical synthesis of -arabinofuranosyl containing oligosaccharides derived from plant cell wall extensins. Org. Biomol. Chem. 11(31): 5136-5146.

208. Wang, Z., Z. Chinoy, S. Ambre, W. Peng, R. McBride, R.P. de Vries, J. Glushka, J.C. Paulson, and G.J. Boons. 2013. A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science 341(6144): 379-383. Highlighted in Science; C&EN; Nature News; Nature Methods: Kiessling, L. L. and M.B. Kraft. 2013. A path to complex carbohydrates. Science 341(6144): 357-358; Arnaud, C.H. 2013. Branching out in different ways. Carbohydrate chemistry: New synthetic strategy leads to asymmetrically branched N-glycans. Chem. Eng. News 91(30): 9; Johnston, R. 2013. Asymmetrical glycans synthesized in lab. Nature, doi:10.1038/nature. 2013.13454; Eisenstein, M. 2013. Constructing complicated carbohydrates. Nat. Methods 10(10): 932.

207. Arumugam, S., S.V. Orski, N.E. Mbua, C. McNitt, G.J. Boons, J. Locklin, and V.V. Popik. 2013. Photo-click chemistry strategies for spatiotemporal control of metal-free ligation, labeling, and surface derivatization. Pure Appl. Chem. 85(7): 1499-1513.

206. Mbua, N.E., H. Flanagan-Steet, S. Johnson, M.A. Wolfert, G.J. Boons, and R. Steet. 2013. Abnormal accumulation of sialylated glycoproteins visualized in Niemann-Pick Type C cells using the chemical reporter strategy. Proc. Natl. Acad. Sci. U. S. A. 110(25): 10207-10212.

205. Zong, C., A. Venot, O. Dhamale, and G.J. Boons. 2013. Fluorous supported modular synthesis of heparin sulfate oligosaccharides. Org. Lett. 15(2): 342-345.

204. Talabnin, K., K. Aoki, P. Saichua, S. Wongkham, S. Kaewkes, G.J. Boons, B. Sripa, and M. Tiemeyer. 2013. Stage-specific expression and antigenicity of glycoprotein glycans isolated from the human liver fluke, Opisthorchis viverrini. Int. J. Parasitol. 43(1): 37-50.

203. Leach III, F.E., S. Arungundram, K. Al-Mafraji, A. Venot, G.J. Boons, and I.J. Amster. 2012. Electron detachment dissociation of synthetic heparan sulfate glycosaminoglycan tetrasaccharides varying in degree of sulfation and hexuronic acid stereochemistry. Int. J. Mass Spectrom. 330-332: 152-159.

202. Friscourt, F., C.J. Fahrni, and G.J. Boons. 2012. A fluorogenic probe for the catalyst-free detection of azide-tagged molecules. J. Am. Chem. Soc. 134(45): 18809-18815.

201. Mo, K.F., X. Li, H. Li, L.Y. Low, C.P. Quinn, and G.J. Boons. 2012. Endolysins of Bacillus anthracis bacteriophages recognize unique carbohydrate epitopes of vegetative cell wall polysaccharides with high affinity and selectivity. J. Am. Chem. Soc. 134(37): 15556–15562.

200. Boltje, T.J., W. Zhong, J. Park, M.A. Wolfert, W. Chen, and G.J. Boons. 2012. Chemical synthesis and immunological evaluation of the inner-core oligosaccharide of Francisella tularensis. J. Am. Chem. Soc. 134(34): 14255-14262.

199. Fang, T., K.F. Mo, and G.J. Boons. 2012. Stereoselective assembly of complex oligosaccharides using anomeric sulfonium ions as glycosyl donors. J. Am. Chem. Soc. 134(17): 7545-7552.

198. Guo, J., G. Chen, X. Ning, X. Li, J. Zhou, A. Jagielska, B. Xu, and G.J. Boons. 2012. A chemo-mechanical tweezer for single molecular characterization of soft materials. Chem. Eur. J. 18(15): 4568-4574.

197. Friscourt, F., P.A. Ledin, N.E. Mbua, H.R Flanagan-Steet, M.A. Wolfert, R. Steet, and G.J. Boons. 2012. Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells. J. Am. Chem. Soc. 134(11): 5381-5389.

196. Lawrence, R., J.R. Brown, K. Al-Mafraji, W.C. Lamanna, J.R. Beitel, G.J. Boons, J.D. Esko, and B.E. Crawford. 2012. Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nat. Chem. Biol. 8(2): 197-204.

195. Nguyen T.K., S. Arungundram, V.M. Tran, K. Raman, K. Al-Mafraji, A. Venot , G.J. Boons, and B. Kuberan. 2012. A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of D-glucosaminyl 3-O-sulfotransferase-3a. Mol. BioSyst. 8: 609-614.

194. van der Linden, W.A., N. Li, S. Hoogendoorn, M. Ruben, M. Verdoes, J. Guo, G.J. Boons, G.A. van der Marel, B.I. Florea, H.S. Overkleeft. 2012. Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study. 2011. Bioorg. Med. Chem. 20(2): 662-666.

193. Lakshminarayanan, V., P. Thompson, M.A. Wolfert, T. Buskas, J.M. Bradley, L.B. Pathangey, C.S. Madsen, P.A. Cohen, S.J. Gendler, and G.J. Boons. 2012. Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine. Proc. Natl. Acad. Sci. U. S. A. 109(1): 261-266.

192. Akimoto, Y., Y. Miura, T. Toda, M.A. Wolfert, L. Wells, G.J. Boons, G.W. Hart, T. Endo, and H. Kawakami. 2011. Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including alpha-actinin 4. Clin. Proteomics 8: 15.

191. Mo, K., T. Fang, S. Stalnaker, P.S. Kirby, M. Liu, L. Wells, M. Pierce, D.H. Live and G.J. Boons. 2011. Synthetic, structural and biosynthetic studies of an unusual phospho-glycopeptide derived from alpha-dystroglycan. J. Am. Chem. Soc. 133(36): 14418-14430.

190. Zhao, P., R. Viner, C.F. Teo, G.J. Boons, D. Horn, and L. Wells. 2011. Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment. J. Proteome Res. 10(9): 4088-4104.

189. Mbua, N.E., J. Guo, M.A. Wolfert, R. Steet, and G.J. Boons. 2011. Strain-promoted alkyne-azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesis. ChemBioChem 12(12): 1912-1921.

188. Mir, M., J. Asong, X. Li, J. Cardot, G.J. Boons, and R.N. Husson. 2011. The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog. 7(7): e1002182.

187. Li, X., J. Guo, J. Asong, M.A. Wolfert, and G.J. Boons. 2011. Multifunctional surface modification of gold-stabilized nanoparticles by bioorthogonal reactions. J. Am. Chem. Soc. 133(29): 11147-11153. Highlighted in ChemViews Magazine: News. 2011. Modular modification of gold nanoparticles. ChemViews Magazine of ChemPubSoc Europe, news 1236817.

186. Kashyap, D.R., M. Wang, L.H. Liu, G.J. Boons, D. Gupta, and R. Dziarski. 2011. Peptidoglycan recognition proteins kill bacteria by inducing suicide through protein-sensing two-component systems. Nat. Med. 17(6): 676-683.

185. Leach III, F.E., J.J. Wolff, Z. Xiao, M. Ly, T.N. Laremore, S. Arungundram, K. Al-Mafraji, A. Venot, G.J. Boons, R.J. Linhardt, I.J. Amster. 2011. Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates. Eur. J. Mass Spectrom. 17(2): 167-176.

184. Saile, E., G.J. Boons, T. Buskas, R.W. Carlson, E.L. Kannenberg, J.R. Barr, A.E. Boyer, M. Gallegos-Candela, and C.P. Quinn. 2011. Antibody responses to a spore carbohydrate antigen as a marker of non-fatal inhalation anthrax in rhesus macaques. Clin. Vaccine Immunol. 18(5): 743-748.

183. van der Wel, H., J.M. Johnson, Y. Xu, C.V. Karunaratne, K.D. Wilson, Y. Vohra, G.J. Boons, C.M. Taylor, B. Bendiak, and C.M. West. 2011. Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and -N-acetylglucosaminyltransferase enzymes involved in O2-signaling in Dictyostelium. Biochemistry 50(10): 1700-1713.

182. Oh H.B., F.E. Leach III, S. Arungundram, K. Al-Mafraji, A. Venot, G.J. Boons, and I.J. Amster. 2011. Multivariate analysis of electron detachment dissociation and infrared multiphoton dissociation mass spectra of heparan sulfate tetrasaccharides differing only in hexuronic acid stereochemistry. J. Am. Soc. Mass Spectrom. 22(3): 582-590.

181. Sanders, B.C., F. Friscourt, P.A. Ledin, N.E. Mbua, S. Arumugam, J. Guo, T.J. Boltje, V.V. Popik, and G.J. Boons. 2011. Metal-free sequential [3+2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity. J. Am. Chem. Soc. 133(4): 949-957. Highlighted in JACS Beta: JACS Select #18, 2012. The Chemistry-Glycobiology Frontier (B. Imperiali, Guest Editor).

180. Boltje, T.J., J.H. Kim, J. Park, and G.J. Boons. 2011. Stereoelectronic effects determine oxacarbenium vs -sulfonium ion mediated glycosylations. Org. Lett. 13(2): 284-287.

179. Ledin, P.A., F. Friscourt, J. Guo, and G.J. Boons. 2011. Convergent assembly and surface modification of multifunctional dendrimers by three consecutive click reactions. Chem. Eur. J. 17(3): 839-846.

178. Guo, J., G. Chen, X. Ning, M.A. Wolfert, X. Li, B. Xu, and G.J. Boons. 2010. Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions. Chem. Eur. J. 16(45): 13360-13366. Selected for frontispiece. Highlighted in Angew. Chem. Int. Ed.: Manova R., T.A. van Beek, and H. Zuilhof. 2011. Surface functionalization by strain-promoted alkyne-azide click reactions. Angew. Chem. Int. Ed. 50(24): 5428-5430.

177. Friscourt, F. and G.J. Boons. 2010. One-pot three-step synthesis of 1,2,3-triazoles by copper-catalyzed cycloaddition of azides with alkynes formed by a Sonogashira cross-coupling and desilylation. Org. Lett. 12(21): 4936-4939.

176. Boons G.J. 2010. Liposomes modified by carbohydrate ligands can target B-cells for the treatment of B-cell lymphomas. Expert Rev. Vaccines. 9(11): 1251-1256.

175. Boltje, T.J., C. Li, and G.J. Boons. 2010. Versatile set of orthogonal protecting groups for the preparation of highly branched oligosaccharides. Org. Lett. 12(20): 4636-4639.

174. Gaekwad J., Y. Zhang, W. Zhang, J, Reeves, M.A. Wolfert, and G.J. Boons. 2010. Differential induction of innate immune responses by synthetic lipid A derivatives. J. Biol. Chem. 285(38): 29375-29386.

173. Berghaus L.J., J.N. Moore, D.J. Hurley, M.L. Vandenplas, B.P. Fortes, M.A. Wolfert, and G.J. Boons. 2010. Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4. Comp. Immunol. Microbiol. Infect. Dis. 33(5): 443-454.

172. Boltje, T.J., J.H. Kim, J. Park, and G.J. Boons. 2010. Chiral-auxiliary-mediated 1,2-cis-glycosylations for the solid-supported synthesis of a biologically important branched -glucan. Nat. Chem. 2(7): 552-557.

171. Teo C.F., S. Ingale, M.A. Wolfert, G.A. Elsayed, L.G. Nöt, J.C. Chatham, L. Wells, and G.J. Boons. 2010. Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat. Chem. Biol. 6(5): 338-343.

170. Ning X., R.P. Temming, J. Dommerholt, J. Guo, D.B. Ania, M.F. Debets, M.A. Wolfert, G.J. Boons, and F.L. van Delft. 2010. Protein modification by strain-promoted alkynenitrone cycloaddition. Angew. Chem. Int. Ed. 49(17): 3065-3068. Selected as “Hot Paper”.

169. Maiti, K.K., M. DeCastro, A.M. Abdel-Aal El-Sayed, M.I. Foote, M.A. Wolfert, and G.J. Boons. 2010. Chemical synthesis and proinflammatory responses of monophosphoryl lipid A adjuvant candidates. Eur. J. Org. Chem. (1): 80-91.

168. Arungundram, S., K. Al-Mafraji, J. Asong, F.E. Leach III, I.J. Amster, A. Venot, J.E. Turnbull, and G.J. Boons. 2009. Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies. J. Am. Chem. Soc. 131(47): 17394-17405. Highlighted in C&EN: Borman, S.A. 2009. Giant leap for obstinate targets. Sugar chemistry: Parallel combinatorial synthesis yields 12 hard-to-make oligosaccharides. Chemical & Engineering News, 87(47): 10.

167. Poloukhtine, A.A., N.E. Mbua, M.A. Wolfert, G.J. Boons, and V.V. Popik. 2009. Selective labeling of living cells by a photo-triggered click reaction J. Am. Chem. Soc. 131(43): 15769-15776.

166. Boltje, T.J., T. Buskas, and G.J. Boons. 2009. Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research. Nat. Chem. 1(8): 611-622.

165. Wang, Z.A., H. van der Wel, Y. Vohra, T. Buskas, G.J. Boons, and C.M. West. 2009. Role of a cytoplasmic dual-function glycosyltransferase in O2 regulation of development in Dictyostelium. J. Biol. Chem. 284(42): 28896-28904.

164. Buskas, T., P. Thompson, and G.J. Boons. 2009. Immunotherapy for cancer: Synthetic carbohydrate-based vaccines. Chem. Commun. (36): 5335-5349.

163. Vohra, Y., T. Buskas, and G.J. Boons. 2009. Rapid assembly of oligosaccharides: a highly convergent strategy for the assembly of a glycosylated amino acid derived from PSGL-1. J. Org. Chem. 74(16): 6064-6071.

162. Leoff C., E. Saile, J. Rauvolfova, C.P. Quinn, A.R. Hoffmaster, W. Zhong, A.S. Mehta, G.J. Boons, R.W. Carlson, and E.L. Kannenberg. 2009. Secondary cell wall polysaccharides of Bacillus anthracis are antigens that contain specific epitopes which cross-react with three pathogenic Bacillus cereus strains that caused severe disease, and other epitopes common to all the Bacillus cereus strains tested. Glycobiology 19(6): 665-673.

161. Marina-García N., L. Franchi, Y.G. Kim, Y. Hu, D.E. Smith, G.J. Boons, and G. Nunez. 2009. Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J. Immunol. 182(7): 4321-4327.

160. Asong, J., M.A. Wolfert, K. Maiti, D. Miller, and G.J. Boons. 2009. Binding and cellular activation studies reveal that Toll-like receptor 2 can differentially recognize peptidoglycan from Gram-positive and Gram-negative bacteria. J. Biol. Chem. 284(13): 8643-8653.

159. Chen, G., X. Ning, B. Park, G.J. Boons, and B. Xu. 2009. Simple, clickable protocol for atomic force microscopy tip modification and its application for trace ricin detection by recognition imaging. Langmuir 25(5): 2860-2864.

158. Ferrand, Y., E. Klein, N.P. Barwell, M.P. Crump, J. Jimenez-Barbera, C. Vicent, G.J. Boons, S. Ingale, and A.P. Davis. 2009. A synthetic lectin for O-linked -N-acetylglucosamine. Angew. Chem. Int. Ed. 48(10): 1775-1779. Selected for inside cover picture.

157. Ingale, S., M.A. Wolfert, T. Buskas, and G.J. Boons. 2009. Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting Toll-like receptors. ChemBioChem 10(3): 455-463.

156. Kuntz, D.A., W. Zhong, J. Guo, D.R. Rose, and G.J. Boons. 2009. The molecular basis of inhibition of Golgi -mannosidase II by mannostatin A. ChemBioChem 10(2): 268-277.

155. Park, J., T.J. Boltje, and G.J. Boons. 2008. Direct and stereoselective synthesis of -linked 2-deoxyglycosides. Org. Lett. 10(19): 4367-4370.

154. Zhang, Y., J. Gaekwad, M.A. Wolfert, and G.J. Boons. 2008. Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4. Org. Biomol. Chem. 6(18): 3371-3381.

153. Vohra, Y., M. Vasan, A. Venot, and G.J. Boons. 2008. One-pot synthesis of oligosaccharides by combining reductive openings of benzylidene acetals and glycosylations. Org. Lett. 10(15): 3247-3250.

152. Rauvolfova, J., A. Venot, and G.J. Boons. 2008. Chemo-enzymatic synthesis of C-9 acetylated sialosides. Carbohydr. Res. 343(10-11): 1605-1611.

151. Vasan M., J. Rauvolfova, M.A. Wolfert, C. Leoff, E.L. Kannenberg, C.P. Quinn, R.W. Carlson, and G.J. Boons. 2008. Chemical synthesis and immunological properties of oligosaccharides derived from the vegetative cell wall of Bacillus anthracis. ChemBioChem 9(11): 1716-1720.

150. Zhong W., D.A. Kuntz, B. Ember, H. Singh, K.W. Moremen, D.R. Rose, and G.J. Boons. 2008. Probing the substrate specificity of Golgi -mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J. Am. Chem. Soc. 130(28): 8975-8983.

149. Marina-Garcia, N., L. Franchi, Y.G. Kim, D. Miller, C. McDonald, G.J. Boons, and G. Nunez. 2008. Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via Cryopyrin/NLRP3 independently of Nod2. J. Immunol. 180(6): 4050-4057.

148. Ning, X., J. Guo, M.A. Wolfert, and G.J. Boons. 2008. Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast Huisgen cycloadditions. Angew. Chem. Int. Ed. 47(12): 2253-2255. Selected as a VIP paper.

147. Rao, Y., T. Buskas, A. Albert, M.A. O’Neill, M.G. Hahn, and G.J. Boons. 2008. Synthesis and immunological properties of a tetrasaccharide portion of the B side chain of rhamnogalacturonan II (RG-II). ChemBioChem 9(3): 381-388.

146. Zhang, Y., J. Gaekwad, M.A. Wolfert, and G.J. Boons. 2008. Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis. Chem. Eur. J. 14(2): 558-569.

145. Ingale, S., M.A. Wolfert, J. Gaekwad, T. Buskas, and G.J. Boons. 2007. Robust immune responses elicited by a fully synthetic three-component vaccine. Nat. Chem. Biol. 3(10): 663-667. Highlighted in Nat. Chem. Biol.: Bundle, D.R. 2007. A carbohydrate vaccine exceeds the sum of its parts. Nat. Chem. Biol. 3(10): 605-606.

144. Li, X., S. Wang, J. Qi, S.F. Echtenkamp, R. Chatterjee, M. Wang, G.J. Boons, R. Dziarski, and D. Gupta. 2007. Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. Immunity. 27(3): 518-529.

143. Rao, Y. and G.J. Boons. 2007. A highly convergent chemical synthesis of conformational epitopes of rhamnogalacturonan II. Angew. Chem. Int. Ed. 46(32): 6148-6151.

142. Zhang, Y., M.A. Wolfert, and G.J. Boons. 2007. The influence of the long chain fatty acid on the antagonistic activities of Rhizobium sin-1 lipid A. Bioorg. Med. Chem. 15(14): 4800-4812.

141. Vasan M., M.A. Wolfert, and G.J. Boons. 2007. Agonistic and antagonistic properties of a Rhizobium sin-1 lipid A modified by an ether-linked lipid. Org. Biomol. Chem. 5(13): 2087-2097.

140. Cho, S., Q. Wang, C.P. Swaminathan, D. Hesek, M. Lee, G.J. Boons, S. Mobashery, and R.A. Mariuzza. 2007. Structural insights into the bacterial mechanism of human peptidoglycan recognition proteins. Proc. Natl. Acad. Sci. U. S. A. 104(21): 8761-8766.

139. Park, J., S. Kawatkar, J.H. Kim, and G.J. Boons. 2007. Stereoselective glycosylations of 2-azido-2-deoxy-glucosides using intermediate sulfonium ions. Org. Lett. 9(10): 1959-1962.

138. Zhang, Y., J. Gaekwad, M.A. Wolfert, and G.J. Boons. 2007. Modulation of innate immune responses with synthetic lipid A derivatives. J. Am. Chem. Soc. 129(16): 5200-5216.

137. Liu, S., A. Venot, L. Meng, F. Tian, K.W. Moremen, G.J. Boons, and J.H. Prestegard. 2007. Spin-labeled analogs of CMP-NeuAc as NMR probes of the -2,6-sialyltransferase ST6Gal I. Chem. Biol. 14(4): 409-418.

136. Wolfert, M.A., A. Roychowdhury, and G.J. Boons. 2007. Modifications of the structure of peptidoglycan is a strategy to avoid detection by nucleotide-binding oligomerization domain protein 1. Infect. Immun. 75(2): 706-713. Selected for IAI Spotlight.

135. Mehta, A., E. Saile, W. Zhong, T. Buskas, R. Carlson, E. Kannenberg, Y. Reed, C.P. Quinn, and G.J. Boons. 2006. Synthesis and antigenic analysis of the Bc1A glycoprotein oligosaccharide from the Bacillus anthracis exosporium. Chem. Eur. J. 12(36): 9136-9149. Selected for frontispiece.

134. Ingale, S., T. Buskas, and G.J. Boons. 2006. Synthesis of glyco(lipo)peptides by liposome-mediated native chemical ligation Org. Lett. 8(25): 5785-5788.

133. Kim, J.H., H. Yang, V. Khot, D. Whitfield, and G.J. Boons. 2006. Stereoselective glycosylations using (R)- or (S)-(ethoxycarbonyl)benzyl chiral auxiliaries at C-2 of glycopyranosyl donors. Eur. J. Org. Chem. (22): 5007-5028. Selected for cover picture.

132. Zhu, X., S. Kawatkar, Y. Rao, and G.J. Boons. 2006. Practical approach for the stereoselective introduction of -arabinofuranosides. J. Am. Chem. Soc. 128(36): 11948-11957. Highlighted in C&EN: Borman, S.A. 2007. Bacterial wall component made. Chemical & Engineering News 85(32): 6.

131. Alphey, M.S., A. Burton, M.D. Urbaniak, G.J. Boons, M.A. Ferguson, and W.N. Hunter. 2006. Tyrpanosoma brucei UDP-galactose-4’-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro--D-galactose. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62(9): 829-834.

130. Guo, J., J. Asong, and G.J. Boons. 2006. Selective inhibition of glycosidases by feedback prodrugs. Angew. Chem. Int. Ed. 45(32): 5345-5348.

129. Buskas, T., S. Ingale, and G.J. Boons. 2006. Glycopeptides as versatile tools for glycobiology. Glycobiology 16(8): 113R-136R.

128. Kawatkar, S., D.A. Kuntz, R.J. Woods, D.R. Rose, and G.J. Boons. 2006. Structural basis of the inhibition of Golgi -mannosidase II by mannostatin A and the role of the thiomethyl moiety in protein-ligand interactions. J. Am. Chem. Soc. 128(25): 8310-8319.

127. Buts, L., A. Garcia-Pino, A. Imberty, N. Amiot, G.J. Boons, S. Beeckmans, W. Versees, L. Wyns, and R. Loris. 2006. Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin. FEBS J. 273(11): 2407-2420.

126. Guan, R., P.H. Brown, C.P. Swaminathan, A. Roychowdhury, G.J. Boons, and R.A. Mariuzza. 2006. Crystal structure of human peptidoglycan recognition protein I bound to a muramyl pentapeptide from Gram-positive bacteria. Protein Science 15(5): 1199-1206.

125. Rao, Y., A. Venot, E.E. Swayze, R.H. Griffey, and G.J. Boons. 2006. Trisaccharide mimetics of the aminoglycoside antibiotic neomycin. Org. Biomol. Chem. 4(7): 1328-1337.

124. Swaminathan, C.P., P.H. Brown, A. Roychowdhury, Q. Wang, R. Guan, N. Silverman, W.E. Goldman, G.J. Boons, and R.A. Mariuzza. 2006. Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc. Natl. Acad. Sci. U. S. A. 103(3): 684-689.

123. Lee, H.S., M.A. Wolfert, Y. Zhang, and G.J. Boons. 2006. The 2-aminogluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF- production induced by enteric LPS. ChemBioChem 7(1): 140-148.

122. Kumar, S., A. Roychowdhury, B. Ember, Q. Wang, R. Guan, R.A. Mariuzza, and G.J. Boons. 2005. Selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition protein I and S. J. Biol. Chem. 280(44): 37005-37012.

121. Roychowdhury, A., M.A. Wolfert, and G.J. Boons. 2005. Synthesis and pro-inflammatory properties of muramyl tripeptides containing lysine and diaminopimelic acid moieties. ChemBioChem 6(11): 2088-2097.

120. Buskas, T., S. Ingale, and G.J. Boons. 2005. Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn-antigen. Angew. Chem. Int. Ed. 44(37): 5985-5988. Selected as a VIP paper. Highlighted in C&EN: Borman, S.A. 2005. Cancer vaccine is best in class: Three-part carbohydrate vaccine elicits strong anticancer response. Chemical & Engineering News 83(37): 10.

119. Buskas, T., Y. Li, and G.J. Boons. 2005. Synthesis of a dimeric Lewis antigen and the evaluation of the epitope specificity of antibodies elicited in mice. Chem. Eur. J. 11(18): 5457-5467.

118. Kim, J.H., H. Yang, J. Park, and G.J. Boons. 2005. A general strategy for stereoselective glycosylations. J. Am. Chem. Soc. 127(34): 12090-12097. Highlighted in C&EN and in Nature: Borman, S.A. 2005. New approach to glycosylation: Technique could facilitate one-pot and automated syntheses of carbohydrates. Chemical & Engineering News 83(34): 11; Flitsch, S.L. 2005. Synthetic chemistry: Glycosylation with a twist. Nature 437: 201-202.

117. Cato, D., T. Buskas, and G.J. Boons. 2005. Highly efficient stereospecific preparation of Tn and TF building blocks using thioglycosyl donors and the Ph2SO/Tf2O promoter system. J. Carbohydr. Chem. 24: 503-516.
116 Siriwardena, A., H. Strachan, S. El-Daher, G. Way, B. Winchester, J. Glushka, K. Moremen, and G.J. Boons. 2005. Potent and selective inhibition of class II -D-mannosidase activity by a bicyclic sulfonium salt. ChemBioChem 6(5): 845-848.

115. Roychowdhury, A. and G.J. Boons. 2005. The synthesis of diaminopimelic acid containing peptidoglycan fragments using metathesis cross couplings. Tetrahedron Lett. 46(10): 1675-1678.

114. Majumdar, D., G.A. Elsayed, T. Buskas, and G.J. Boons. 2005. Synthesis of proteophosphoglycans of Leishmania major and Leishmania mexicana. J. Org. Chem. 70(5): 1691-1697.

113. Guan, R., A. Roychowdhury, B. Ember, S. Kumar, G.J. Boons, and R.A. Mariuzza. 2005. Crystal structure of a peptidoglycan recognition protein (PGRP) in complex with a muramyl tripeptide from Gram-positive bacteria. J. Endotoxin Res. 11(1): 41-46.

112. Kim, J.H., H. Yang, and G.J. Boons. 2005. Stereoselective glycosylations with chiral auxiliaries. Angew. Chem. Int. Ed. 44(6): 947-949. Highlighted in Nature: Research Highlights. 2005 Nature 436: 757.

111. Guan, R., A. Roychowdhury, B. Ember, S. Kumar, G.J. Boons, and R.A. Mariuzza. 2004. Structural basis for peptidoglycan binding by peptidoglycan recognition proteins. Proc. Natl. Acad. Sci. U. S. A. 101(49): 17168-17173.

110. Santhanam, B., M.A. Wolfert, J.N. Moore, and G.J. Boons. 2004. Synthesis and biological evaluation of a lipid A derivative that contains an aminogluconate moiety. Chem. Eur. J. 10(19): 4798-4807.

109. Santhanam, B. and G.J. Boons. 2004. Preparation of a lipid A derivative that contains a 27-hydroxyoctacosanoic acid moiety. Org. Lett. 6(19): 3333-3336.

108. Li, B., S.P. Kawatkar, S. George, H. Strachan, R.J. Woods, A. Siriwardena, K.W. Moremen, and G.J. Boons. 2004. Inhibition of Golgi mannosidase II with mannostatin A analogs: Synthesis, biological evaluation and structure activity relationship studies. ChemBioChem 5(9): 1220-1227.

107. Venot, A., E.E. Swayze, R.H. Griffey, and G.J. Boons. 2004. Disaccharide mimetics of the aminoglycoside antibiotic neamine. ChemBioChem 5(9): 1228-1236.

106. Buskas, T., Y.H. Li, and G.J. Boons. 2004. The immunogenicity of the tumor-associated antigen Lewisy may be suppressed by a bifunctional cross-linker required for coupling to a carrier protein. Chem. Eur. J. 10(14): 3517-3524.

105. Galan, M.C., A.P. Venot, and G.J.Boons. 2004. The design and synthesis of a selective inhibitor of fucosyltransferase VI. Org. & Biomol. Chem. 2(9): 1376-1380.
104 Galan, M.C., C.S. Dodsen, A.P. Venot, and G.J. Boons. 2004. Glycosyltransferase activity can be selectively modulated by chemical modificiations of acceptor substrates. Biorg. Med. Chem. Lett. 14(9): 2205-2208.

103. Narendran P., K. Elsegood, N.J. Leech, W.M. Macindoe, G.J. Boons, and C.M. Dayan. 2004. Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes. Immunology. 111(4): 422-429.

102. Watt, G. and G.J. Boons. 2004. A convergent strategy for the preparation of N-glycan core di, tri- and pentasaccharide thioaldoses for the site-specific glycosylation of peptides and proteins bearing free cysteines. Carbohydr. Res. 339(2): 181-193. Selected for cover picture.

101. Prabhu, A., A.P. Venot, and G.J. Boons. 2003. A new set of orthogonal protecting groups for the modular synthesis of heparan sulfate fragments. Org. Lett. 5(26): 4975-4978.

100. Galan, M.C., A.P. Venot, J. Glushka, A. Imberty, and G.J. Boons. 2003. Chemo-enzymatic synthesis of conformationally constrained oligosaccharides. Org. & Biomol. Chem. 1(22): 3891-3899.

99. Majumdar, D., T. Zhu, and G.J. Boons. 2003. Synthesis of oligosaccharides on soluble high-molecular-weight branched polymers in combination with purification by nanofiltration. Org. Lett. 5(20): 3591-3594.

98. Watt, G., J. Lund, M. Levens, V.S.K. Kolli, R. Jefferis, and G.J. Boons. 2003. Site-specific glycosylation of an aglycosylated human IgG1-Fc antibody protein generates neoglycoproteins with enhanced function. Chem. & Biol. 10(9): 807-814.

97. Elsayed, G.A. and G.J. Boons. 2003. Chemical synthesis of -D-mannosylphosphate serine derivatives: A new class of synthetic glycopeptides. Synlett. (9): 1373-1375.

96. Pinhal-Enfield, G., M. Ramanathan, G. Hasko, S.N. Vogel, A.L. Salzman, G.J. Boons, and S.J. Leibovich. 2003. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9, and adenosine A2A receptors. Am. J. Path. 163(2): 711-721.

95. Galan, M.C., A.P. Venot, and G.J. Boons. 2003. Glycosyltransferase activity can be modulated by small conformational changes of acceptor substrates. Biochemistry 42(28): 8522-8529.

94. Thobhani, S., B. Ember, A. Siriwardena, and G.J. Boons. 2003. Multivalency and the mode of action of bacterial sialidases. J. Am. Chem. Soc. 125(24): 7154-7155. Highlighted in C&EN: Science Concentrates. 2003. Polyvalent ligand inhibits cholera enzyme. Chemical & Engineering News 81(25): 38.

93. Demchenko, A.V, M.A. Wolfert, B. Santhanam, J.N. Moore, and G.J. Boons. 2003. Synthesis and biological evaluation of Rhizobium sin-1 lipid A derivatives. J. Am. Chem. Soc. 125(20): 6103-6112.

92. Geurtsen, R. and G.J. Boons. 2002. Chemoselective glycosylations of sterically hindered glycosyl acceptors. Tetrahedron Lett. 43(55): 9429-9431.

91. Arranz-Plaza, E., A.S. Tracy, A. Siriwardena, J.M. Pierce, and G.J. Boons. 2002. High-avidity, low-affinity multivalent interactions and the block to polyspermy in Xenopus laevis. J. Am. Chem. Soc. 124(44): 13035-13046.

90. Roychowdhury, A., A. Siriwardena, and G.J. Boons. 2002. A highly convergent approach for the synthesis of disaccharide repeating units of peptidoglycan. Tetrahedron Lett. 43(43): 7805-7807.

89. Wolfert, M.A., T.F. Murray, G.J. Boons, and J.N. Moore. 2002. The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan. J. Biol. Chem. 277(42): 39179-39186.

88. Haller, M.F. and G.J. Boons. 2002. Selectively protected disaccharide building blocks for modular synthesis of heparin fragments. Eur. J. Org. Chem. (13): 2033-2038.

87. Elsayed, G.A., T. Zhu, and G.J. Boons. 2002. Demixing libraries of saccharides using a multi-linker approach in combination with a soluble polymeric support. Tetrahedron Lett. 43(26): 4691-4694.

86. Galan, M.C., A.P. Venot, J. Glushka, A. Imberty, and G.J. Boons. 2002. -(2,6)-Sialyltransferase-catalyzed sialylations of conformationally constrained oligosaccharides. J. Am. Chem. Soc. 124(21): 5964-5973.

85. Geurtsen, R. and G.J. Boons. 2002. Regioselective glycosylations in solution and on soluble and insoluble polymeric support. Eur. J. Org. Chem. (9): 1473-1477.

84. De Meo, C., A.V. Demchenko, and G.J. Boons. 2002. Triflouroacetamido substituted sialyl donors for the preparation of sialyl galactosides. Aus. J. Chem. 55(1-2): 131-134.

83. Zhu, T. and G.J. Boons. 2001. Thioglycosides protected as trans-2,3-cyclic carbonates in chemoselective glycosylations. Org. Lett. 3(26): 4201-4203.

82. Clarke, C., R.J. Woods, J. Glushka, A. Cooper, M.A. Nutley, and G.J. Boons. 2001. Involvement of water in carbohydrate-protein binding. J. Am. Chem. Soc. 123(49): 12238-12247.

81. Kearns, D.B., A. Venot, P.J. Bonner, B. Stevens, G.J. Boons, and L.J. Shimkets. 2001. Identification of a developmental chemoattractant in Myxococcus xanthus through metabolic engineering. Proc. Natl. Acad. Sci. U. S. A. 98(24): 13990-13994.

80. Arranz, E. and G.J. Boons. 2001. The 2-(allyloxy) phenyl acetyl ester as a new relay protecting group for oligosaccharide synthesis. Tetrahedron Lett. 42(37): 6469-6471.

79. Siriwardena, A., M.R. Jørgensen, M.A. Wolfert, M.L. Vandenplas, J.N. Moore, and G.J. Boons. 2001. Synthesis and proinflammatory effects of peptidoglycan-derived neoglycopeptide polymers. J. Am. Chem. Soc. 123(33): 8145-8146.

78. De Meo, C., A.V. Demchenko, and G.J. Boons. 2001. A stereoselective approach for the synthesis of -sialosides. J. Org. Chem. 66(16): 5490-5497.

77. McWatt, M. and G.J. Boons. 2001. Parallel combinatorial synthesis of glycodendrimers and their hydrogelation properties. Eur. J. Org. Chem. (13): 2535-2545.

76. Zhu, T. and G.J. Boons. 2001. A highly efficient synthetic strategy for polymeric support synthesis of Lex, Ley, and H-type 2 oligosaccharides. Chem. Eur. J. 7(11): 2382-2389.

75. Demchenko, A.V. and G.J. Boons. 2001. A highly convergent synthesis of a complex oligosaccharide derived from group B type III Streptococcus. J. Org. Chem. 66(8): 2547-2554.

74. Haller, M. and G.J. Boons. 2001. Towards a modular approach for heparin synthesis. J. Chem. Soc., Perkin Trans. 1 (8): 814-822.

73. Boons, G.J. and A.V. Demchenko. Recent advances in O-sialylation. 2000. Chem. Rev. 100(12): 4539-4565.

72. Zhu, T. and G.J. Boons. 2000. Intermolecular aglycon transfer of ethyl thioglycosides can be prevented by judicious choice of protecting groups. Carbohydr. Res. 329(4): 709-715.

71. Zhu, T. and G.J. Boons. 2000. A novel and efficient synthesis of a dimeric Lex oligosaccharide on polymeric support. J. Am. Chem. Soc. 122(41): 10222-10223.

70. Bai, Y., G.J. Boons, A. Burton, M. Johnson, and M. Haller. 2000. Vinyl glycosides in oligosaccharide synthesis . 6. 3-Buten-2-yl 2-azido-2-deoxy glycosides and 3-buten-2-yl-phthalimido-2-deoxy glycosides as novel glycosyl donors. J. Carbohydr. Chem. 19(7): 939-958.

69. Belogi, G., T. Zhu, and G.J. Boons. 2000. Polymer-supported oligosaccharide synthesis by a loading-release-reloading strategy. Tetrahedron Lett. 41(36): 6969-6972.

68. Belogi, G., T. Zhu, and G.J. Boons. 2000. Polystyrylboronic acid as a reusable polymeric support for oligosaccharide synthesis. Tetrahedron Lett. 41(36): 6965-6968.

67. Reichel, F., A.M. Roelofsen, H.P.M. Geurts, S.J. van der Gaast, M.C. Feiters, and G.J. Boons. 2000. Synthesis and supramolecular characterization of a novel class of glycopyranosyl-containing amphiphiles. J. Org. Chem. 65(11): 3357-3366.

66. Zhu, T. and G.J. Boons. 2000. A new set of orthogonal protecting groups for oligosaccharide synthesis on a polymeric support. Tetrahedron: Asymmetry 11(1): 199-205.

65. Boons, G.J. 1999. Combinatorial approaches in oligosaccharide synthesis. Carbohydrates in Europe 27: 28-32.

64. Zhu, T. and G.J. Boons. 1999. A two directional and highly convergent approach for the synthesis of the tumor-associated antigen Globo-H. Angew. Chem. Int. Ed. 38(23): 3495-3497.

63. Geurtsen, R., F. Côté, M.G. Hahn, and G.J. Boons. 1999. Chemoselective glycosylation strategy for the convergent assembly of phytoalexin-elicitor active oligosaccharides and their photoreactive derivatives. J. Org. Chem. 64(21): 7828-7835.

62. Reichel, F., A.M. Roelofsen, H.P.M. Geurts, T.I. Hämäläinen, M.C. Feiters, and G.J. Boons. 1999. Stereochemical dependence of the self-assembly of the immunoadjuvants Pam3Cys and Pam3Cys-Ser. J. Am. Chem. Soc. 121(35): 7989-7997.

61. Demchenko, A.V., E. Rousson, and G.J. Boons. 1999. Stereoselective 1,2-cis-galactosylation assisted by remote neighboring group participation and solvent effects. Tetrahedron Lett. 40(36): 6523-6526.

60. Navarre, N., N. Amiot, A. van Oijen, A. Imberty, A. Poveda, J. Jiménez-Barbero, A. Cooper, M.A. Nutley, and G.J. Boons. 1999. Synthesis and conformational analysis of a conformationally constrained trisaccharide, and complexation properties with concanavalin A. Chem. Eur. J. 5(8): 2281-2294.

59. Demchenko, A.V. and G.J. Boons. 1999. A novel direct glycosylation approach for the synthesis of dimers of N-acetylneuraminic acid. Chem. Eur. J. 5(4): 1278-1283.

58. Johnson, M., C. Arles, and G.J. Boons. 1998. Vinyl glycosides in oligosaccharide synthesis .5. A latent-active glycosylation strategy for the preparation of branched trisaccharide libraries. Tetrahedron Lett. 39(52): 9801-9804.

57. Reichel F. and G.J. Boons. 1998. Sweet promise. Chemistry in Britain 34(9): 43-46.

56. Zhu, T. and G.J. Boons. 1998. A two-directional approach for the solid-phase synthesis of trisaccharide libraries. Angew. Chem. Int. Ed. 37(13-14): 1898-1900.

55. Bowers, S.G., D.M. Coe, and G.J. Boons. 1998. Application of the 2,5-dimethylpyrrole group as a new and orthogonal amine-protecting group in oligosaccharide synthesis. J. Org. Chem. 63(14): 4570-4571.

54. Demchenko, A.V. and G.J. Boons. 1998. A novel and versatile glycosyl donor for the preparation of glycosides of N-acetylneuraminic acid. Tetrahedron Lett. 39(19): 3065-3068.

53. Zhu, T. and G.J. Boons. 1998. A two directional glycosylation strategy for the convergent assembly of oligosaccharides. Tetrahedron Lett. 39(15): 2187-2190.

52. Macindoe, W.M., A.H. van Oijen, and G.J. Boons. 1998. A unique and highly facile method for synthesizing disulfide linked neoglycoconjugates: A new approach for remodelling of peptides and proteins. Chem. Commun. (7): 847-848.

51. Zhu, T. and G.J. Boons. 1998. Two-directional, convergent synthesis of a pentasaccharide that is involved in the hyperacute rejection response in xenotransplantation from pig to man. J. Chem. Soc., Perkin Trans. 1 (5): 857-861.

50. Gibson, R.R., R.P. Dickinson, and G.J. Boons. 1997. Vinyl glycosides in oligosaccharide synthesis .4. Glycosidase-catalysed preparation of substituted allyl glycosides. J. Chem. Soc., Perkin Trans. 1 (22): 3357-3360.

49. Geurtsen, R., D.S. Holmes, and G.J. Boons. 1997. Chemoselective glycosylations .2. Differences in size of anomeric leaving groups can be exploited in chemoselective glycosylations. J. Org. Chem. 62(23): 8145-8154.

48. Reichel, F., P.R. Ashton, and G.J. Boons. 1997. Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate. Chem. Commun. (21): 2087-2088.

47. Burton, A., P. Wyatt, and G.J. Boons. 1997. Preparation of fluorinated galactosyl nucleoside diphosphates to study the mechanism of the enzyme galactopyranose mutase. J. Chem. Soc., Perkin Trans. 1 (16): 2375-2382.

46. Demchenko, A.V., T. Stauch, and G.J. Boons. 1997. Solvent and other effects on the stereoselectivity of thioglycoside glycosidations. Synlett (7): 818-820.

45. Boons, G.J. and T. Zhu. 1997. Novel regioselective glycosylations for the convergent and chemoselective assembly of oligosaccharides. Synlett (7): 809-811.

44. Boons, G.J., S. Bowers, and D.M. Coe. 1997. Trityl ethers in oligosaccharide synthesis: A novel strategy for the convergent assembly of oligosaccharides. Tetrahedron Lett. 38(21): 3773-3776

43. Navarre, N., A.H. van Oijen, and G.J. Boons. 1997. The design and synthesis of a conformationally constrained trisaccharide for probing carbohydrate-protein interactions. Tetrahedron Lett. 38(11): 2023-2026.

42. Demchenko, A.V. and G.J. Boons. 1997. A highly convergent synthesis of a hexasaccharide derived from the oligosaccharide of group B type III Streptococcus. Tetrahedron Lett. 38(9): 1629-1632.

41. Boons, G.J., B. Heskamp, and F. Hout. 1996. Vinyl glycosides in oligosaccharide synthesis: A strategy for the preparation of trisaccharide libraries based on latent-active glycosylation. Angew. Chem. Int. Ed. 35(23-24): 2845-2847.

40. Boons, G.J. and T. Stauch. 1996. Stereoselectivity in glycosidic bond formation: Studies on the anomerisation of thioglycosides. Synlett (9): 906-908.

39. Boons, G.J. 1996. Synthetic oligosaccharides: Recent advances. Drug Discovery Today 1(8): 331-342.

38. Boons, G.J. and S. Isles. 1996. Vinyl glycosides in oligosaccharide synthesis .2. The use of allyl and vinyl glocosides in oligosaccharide synthesis. J. Org. Chem. 61(13): 4262-4271.

37. Boons, G.J. 1996. Recent developments in chemical oligosaccharide synthesis. Contemp. Org. Synth. 3(3): 173-200.
36 Boons, G.J., R. Eveson, S. Smith, and T. Stauch. 1996. A critical evaluation of the cationic coupling of 4-acetoxy-1,3-dioxanes. Synlett (6): 536-538.

35. Boons, G.J., A. Burton, and P. Wyatt. 1996. Glycosyl phosphates: A new latent-active anomeric phosphorylation strategy. Synlett (4): 310-312.

34. Parsons, N.J., G.J. Boons, P.R. Ashton, P.D. Redfern, P. Quirk, Y. Gao, C. Constantinidou, J. Patel, J. Bramley, J.A. Cole, and H. Smith. 1996. Lactic acid is the factor in blood cell extracts which enhances the ability of CMP-NANA to sialylate gonococcal lipopolysaccharide and induce serum resistance. Microb. Pathog. 20(2): 87-100.

33. Boons, G.J. 1996. Strategies in oligosaccharide synthesis. Tetrahedron 52(4): 1095-1121.

32. Boons, G.J., A. Burton, and S. Isles. 1996. A new procedure for the isomerisation of substituted and unsubstituted allyl ethers of carbohydrates. Chem. Commun. (2): 141-142.

31. Boons, G.J., R. Geurtsen, and E. Holmes. 1995. Chemoselective glycosylations .1. Differences in size of anomeric leaving groups can be exploited in chemoselective glycosylations. Tetrahedron Lett. 36(35): 6325-6328.

30. Boons, G.J., S. Isles, and P. Setälä. 1995. An improved procedure for the preparation of 1,6-anhydro sugars. Synlett (7): 755-756.

29. Boons, G.J., J.A. Clase, I.C. Lennon, S.V. Ley, and J. Staunton. 1995. Biosynthesis of tetronasin .4. Preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative bisynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603). Tetrahedron 51(18): 5417-5446.

28. Boons, G.J., R. Downham, K.S. Kim, S.V. Ley, and M. Woods. 1994. Dispiroketals in synthesis .10. Further reactions of dispoke protected lactate and glycolate enolates. Tetrahedron 50(24): 7157-7176.

27. Boons, G.J. and S. Isles. 1994. Vinyl glycosides in oligosaccharide synthesis .1. A new latent-active glycosylation strategy. Tetrahedron Lett. 35(21): 3593-3596.

26. Boons, G.J., I.C. Lennon, S.V. Ley, E.S.E. Owen, J. Staunton, and D.J. Wadsworth. 1994. Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603). Tetrahedron Lett. 35(2): 323-326.

25. Boons, G.J., D.S. Brown, J.A. Clase, I.C. Lennon, and S.V. Ley. 1994. Two new routes to the C19-C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI M139603). Tetrahedron Lett. 35(2): 319-322.

24. Boons, G.J., P. Grice, R. Leslie, S.V. Ley, and L.L. Yeung. 1993. Dispiroketals in synthesis .5. A new opportunity for oligosaccharide synthesis using differentially activated glycosyl donors and acceptors. Tetrahedron Lett. 34(52): 8523-8526.

23. Boons, G.J., G.H. Castle, J.A. Clase, P. Grice, S.V. Ley, and C. Pinel. 1993. Selective acylation and alkylation reactions of diols using dibutyltin dimethoxide. Synlett (12): 913-914.

22. Boons, G.J., D.A. Entwistle, S.V. Ley, and M. Woods. 1993. Dispiroketals in synthesis .4. Enantioselective desymmertrization of glycerol using a C2-symmetric disubstituted bis-dihydropyran. Tetrahedron Lett. 34(35): 5649-5652.

21. Smid, P., F.J.M. Schippers, H.J.G. Broxterman, G.J.P.H. Boons, G.A. van der Marel, and J.H. van Boom. 1993. Use of (chloromethyl)dimethylphenylsilane in sugar chemistry. Stereo-controlled approach to destomic acid and 1-deoxy-nojirimycin. Recl. Trav. Chim. Pays-Bas 112(7-8): 451-456.

20. Ley, S.V., G.J. Boons, R. Leslie, M. Woods, and D.M. Hollinshead. 1993. Dispiroketals in synthesis .3. Selective protection of diequatorial vicinal diols in carbohydrates. Synthesis (7): 689-692.

19. Smid, P., W.P.A. Jörning, A.M.G. van Duuren, G.J.P.H. Boons, G. A. van der Marel, and J.H. van Boom. 1992. Stereoselective synthesis of a dimer containing an -linked 2-acetamido-4-amino-2,4,6-trideoxy-D-galactopyranose (sugp) unit. J. Carbohydrate Chem. 11(7): 849-865.

18. Noort, D., N.C.R. van Straten, G.J.P.H. Boons, G.A. van der Marel, X. Bossuyt, N. Blanckaert, G.J. Mulder, and J.H. van Boom. 1992. Synthesis of a potential inhibitor of UDP-glycoronosyltransferase. Biomed. Chem. Lett. 2(6): 583-588.

17. van der Klein, P.A.M., W. Filemon, G.J.P.H. Boons, G.H. Veeneman, G.A. van der Marel, and J.H. van Boom. 1992. Synthesis of a cell wall component of Haemophilus (Actionobacillus) Pleuropneumoniae serotype 5. Tetrahedron 48(22): 4649-4658.

16. Boons, G.J.P.H., M. Overhand, G.A. van der Marel, and J.H. van Boom. 1992. Synthesis of two branched heptopyranoside (L,D-Hepp)-containing trisaccharides of the inner-core region of Citrobacter PCM 1487. Recl. Trav. Chim. Pays-Bas 111(3): 144-148.

15. Boons, G.J.P.H., F.L. van Delft, P.A.M. van der Klein, G.A. van der Marel, and J.H. van Boom. 1992. Synthesis of LD-Hepp and KDO containing disaccharide and tetrasaccharide derivatives of Neisseria meningitidis inner-core region via iodonium ion promoted glycosidations. Tetrahedron 48(5): 885-904.

14. Boons, G.J.P.H., R. Steyger, M. Overhand, G.A. van der Marel, and J.H. van Boom. 1991. Synthesis of naturally occurring LD-Hepp containing disaccharides. J. Carbohydr. Chem. 10(6): 995-1007.

13. Verheul, A.F.M., G.J.P.H. Boons, G.A. van der Marel, J.H. van Boom, H.J. Jennings, H. Snippe, J. Verhoef. P. Hoogerhout, and J.T. Poolman. 1991. Minimal oligosaccharide structures required for induction of immune responses against meningococcal immunotype L1, L2, and L3,7,9 lipopolysaccharides determined by using synthetic oligosaccharide-protein conjugates. Infect. Immun. 59(10): 3566-3573.

12. Boons, G.J.P.H., P. Hoogerhout, J.T. Poolman, G.A. van der Marel, and J.H. van Boom. 1991. Preparation of a well-defined sugar-peptide conjugate: A possible approach to a synthetic vaccine against Neisseria meningitidis. Bioorg. Med. Chem. Lett. 1(6): 303-308.

11. Verheul, A.F.M., H. Snippe, J. Verhoef, P. Hoogerhout, J.T. Poolman, G.J.P.H. Boons, G.A. van der Marel, and J.H. van Boom. 1991. Immunogenicity of meningococcal LPS derived oligosaccharide-protein conjugates using isolated and synthetic oligosaccharides. Neisseriae 1990: 301-306.

10. Boons, G.J.P.H., C.J.J. Elie, G.A. van der Marel, and J.H. van Boom. 1990. Use of (phenyldimethylsilyl)methoxymethyl and (phenyldimethylsilyl)methyl ethers as protecting groups for sugar hydroxyls. Tetrahedron Lett. 31(15): 2197-2200.

9. van der Klein P.A.M., G.J.P.H. Boons, G.H. Veeneman, G.A. van der Marel, and J.H. van Boom. 1990. Iodonium ion promoted cyclization: A convenient approach to glycosyl donors of 3-deoxy-D-manno-2-octulosonic acid (KDO). Synlett (6): 311-313.

8. Noort, D., G.H. Veeneman, G.J.P.H. Boons, G.A. van der Marel, G.J. Mulder, and J.H. van Boom. 1990. Iodonium ion promoted reactions at the anomeric C-2 centre of 1-methylene sugars. Synlett (4): 205-206.

7. Boons, G.J.P.H., P.A.M. van der Klein, G.A. van der Marel, and J.H. van Boom. 1990. A practical route toward the preparation of 4,5:7,8-di-O-isopropylidene KDO ethyl ester. Recl. Trav. Chim. Pays-Bas 109(4): 273-276.

6. van der Klein, P.A.M., G.J.P.H. Boons, G.H. Veeneman, G.A. van der Marel, and J. H. van Boom. 1989. An efficient route to 3-deoxy-D-manno-2-octulosonic acid (KDO) derivatives via a 1,4-cyclic sulfate approach. Tetrahedron Lett. 30(40): 5477-5480.

5. Boons, G.J.P.H., M. Overhand, G.A. van der Marel, and J.H. van Boom. 1989. Application of the dimethyl(phenyl)silyl group as a masked form of the hydroxy group in the synthesis of an L-glycero--D-manno-heptopyranoside-containing trisaccharide from the dephosphorylated inner core region of Neisseria meningitidis. Angew. Chem. Int. Ed. 28(11): 1504-1506.

4. Boons, G.J.P.H., M. Overhand, G.A. van der Marel, and J.H. van Boom. 1989. Synthesis of a trisaccharide of the inner core region of Citrobacter PCM 187 lipopolysaccharide that contains L-glycero--D-manno-heptopyranosyl units. Carbohydr. Res. 192: c1-c4.

3. Boons, G.J.P.H., G.A. van der Marel, J.T. Poolman, and J.H. van Boom. 1989. Synthesis of L-glycero--D-manno-heptopyranose-containing disaccharide derivatives of the Neisseria meningtitidis dephosphorylated inner-core region. Recl. Trav. Chim. Pays-Bas 108(10): 339-343.

2. Boons, G.J.P.H., G.A. van der Marel, and J. H. van Boom. 1989. A versatile and new highly stereoselective approach to the synthesis of L-glycero-D-manno-heptopyranosides. Tetrahedron Lett. 30(2): 229-232.

1. Boons, G.J.P.H., P.A.M. van der Klein, G.A. van der Marel, and J. H. van Boom. 1988. Synthesis of L-glycero-D-manno-heptose. Recl. Trav. Chim. Pays-Bas 107(7-8): 507-508.